Regulation of osteoblast differentiation by transcription factors
Article first published online: 22 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Cellular Biochemistry
Volume 99, Issue 5, pages 1233–1239, 1 December 2006
How to Cite
Komori, T. (2006), Regulation of osteoblast differentiation by transcription factors. J. Cell. Biochem., 99: 1233–1239. doi: 10.1002/jcb.20958
- Issue published online: 27 OCT 2006
- Article first published online: 22 JUN 2006
- Manuscript Accepted: 19 MAY 2006
- Manuscript Received: 13 JAN 2006
- Ministry of Education, Culture, Sports, Science, and Technology
- The Naito Foundation
- transcription factor
Runx2, osterix, and β-catenin are essential for osteoblast differentiation. Runx2 directs multipotent mesenchymal cells to an osteoblastic lineage, and inhibits them from differentiating into the adipocytic and chondrocytic lineages. After differentiating to preosteoblasts, β-catenin, osterix, and Runx2 direct them to immature osteoblasts, which produce bone matrix proteins, blocking their potential to differentiate into the chondrocytic lineage. Runx2 inhibits osteoblast maturation and the transition into osteocytes, keeping osteoblasts in an immature stage. Other transcription factors including Msx1, Msx2, Dlx5, Dlx6, Twist, AP1(Fos/Jun), Knox-20, Sp3, and ATF4 are also involved in osteoblast differentiation. To gain an understanding of bone development, it is important to position these transcription factors to the right places in the processes of osteoblast differentiation. J. Cell. Biochem. 99: 1233–1239, 2006. © 2006 Wiley-Liss, Inc.