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Journal of Cellular Biochemistry

Immune cells as anti-cancer therapeutic targets and tools

Authors

  • Magnus Johansson,

    1. Department of Pathology, University of California, San Francisco, 2340 Sutter St., San Francisco, California 94143
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  • Tingting Tan,

    1. Department of Pathology, University of California, San Francisco, 2340 Sutter St., San Francisco, California 94143
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  • Karin E. de Visser,

    1. Department of Pathology, University of California, San Francisco, 2340 Sutter St., San Francisco, California 94143
    2. Department of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
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  • Lisa M. Coussens

    Corresponding author
    1. Department of Pathology, University of California, San Francisco, 2340 Sutter St., San Francisco, California 94143
    2. Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143
    • Department of Pathology, University of California, San Francisco, 2340 Sutter Street, N-221, San Francisco, CA 94143.
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Abstract

Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanced pro-tumor humoral and/or innate immunity (inflammation), are significant factors influencing malignant outcome. Here, we discuss therapeutic implications from clinical data and experimental studies using de novo immune-competent mouse models of cancer development that together are revealing molecular and cellular mechanisms underlying interactions between immune cells and evolving neoplastic cells that regulate cancer outcome. Understanding the functionally significant links between adaptive and innate immunity that regulate cancer development will open new therapeutic opportunities to manipulate aspects of immunobiology and minimize lethal effects of cancer development. J. Cell. Biochem. 101: 918–926, 2007. © 2007 Wiley-Liss, Inc.

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