Prospect

Centromeres in cell division, evolution, nuclear organization and disease

  1. Amanda Gonçalves dos Santos Silva1,2,
  2. Rahul Sarkar1,3,
  3. Jana Harizanova1,
  4. Amanda Guffei1,
  5. Michael Mowat1,
  6. Yuval Garini4,
  7. Sabine Mai1,*

Article first published online: 18 APR 2008

DOI: 10.1002/jcb.21766

Issue

Journal of Cellular Biochemistry

Journal of Cellular Biochemistry

Special Issue: Nuclear Microenvironments in Cancer Series

Volume 104, Issue 6, pages 2040–2058, 15 August 2008

Additional Information

How to Cite

Gonçalves dos Santos Silva, A., Sarkar, R., Harizanova, J., Guffei, A., Mowat, M., Garini, Y. and Mai, S. (2008), Centromeres in cell division, evolution, nuclear organization and disease. J. Cell. Biochem., 104: 2040–2058. doi: 10.1002/jcb.21766

Author Information

  1. 1

    Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada

  2. 2

    Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil

  3. 3

    Department of Imaging Research, Sunnybrook Health Sciences Center, Toronto, Canada

  4. 4

    Department of Physics and Nanotechnology Institute, Bar Ilan University, Ramat Gan, Israel

*Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg MB R3E 0V9, Canada.

Publication History

  1. Issue published online: 22 JUL 2008
  2. Article first published online: 18 APR 2008
  3. Manuscript Accepted: 22 FEB 2008
  4. Manuscript Received: 20 FEB 2008

Funded by

  • Canadian Institutes of Health Research
  • Komen Foundation for Breast Cancer
  • National Cancer Institute of Canada
  • Canadian Cancer Society
  • CancerCare Manitoba Foundation
  • Israel Science Foundation—FIRST Program

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (374K)

Keywords:

  • centromere;
  • cell division;
  • evolution;
  • cancer;
  • 3D nucleus;
  • imaging

Abstract

As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division. J. Cell. Biochem. 104: 2040–2058, 2008. © 2008 Wiley-Liss, Inc.

View Full Article (HTML) Get PDF (374K)