Journal of Cellular Biochemistry

Centromeres in cell division, evolution, nuclear organization and disease

Authors

  • Amanda Gonçalves dos Santos Silva,

    1. Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada
    2. Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo (UNIFESP), São Paulo/SP, Brazil
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  • Rahul Sarkar,

    1. Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada
    2. Department of Imaging Research, Sunnybrook Health Sciences Center, Toronto, Canada
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  • Jana Harizanova,

    1. Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Amanda Guffei,

    1. Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Michael Mowat,

    1. Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Yuval Garini,

    1. Department of Physics and Nanotechnology Institute, Bar Ilan University, Ramat Gan, Israel
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  • Sabine Mai

    Corresponding author
    1. Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada
    • Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg MB R3E 0V9, Canada.
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Abstract

As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division. J. Cell. Biochem. 104: 2040–2058, 2008. © 2008 Wiley-Liss, Inc.

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