Neural differentiation of human embryonic stem cells
Article first published online: 29 AUG 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Cellular Biochemistry
Volume 105, Issue 3, pages 633–640, 15 October 2008
How to Cite
Dhara, S. K. and Stice, S. L. (2008), Neural differentiation of human embryonic stem cells. J. Cell. Biochem., 105: 633–640. doi: 10.1002/jcb.21891
- Issue published online: 19 SEP 2008
- Article first published online: 29 AUG 2008
- Manuscript Accepted: 17 JUL 2008
- Manuscript Received: 15 JUL 2008
- Aruna Biomedical, Inc.
- National Institute of Health. Grant Numbers: HL074303, NS053272
- human embryonic stem cells;
- neural differentiation;
- cell signaling;
- regional specification
Availability of human embryonic stem cells (hESC) has enhanced human neural differentiation research. The derivation of neural progenitor (NP) cells from hESC facilitates the interrogation of human embryonic development through the generation of neuronal subtypes and supporting glial cells. These cells will likely lead to novel drug screening and cell therapy uses. This review will discuss the current status of derivation, maintenance and further differentiation of NP cells with special emphasis on the cellular signaling involved in these processes. The derivation process affects the yield and homogeneity of the NP cells. Then when exposed to the correct environmental signaling cues, NP cells can follow a unique and robust temporal cell differentiation process forming numerous phenotypes. J. Cell. Biochem. 105: 633–640, 2008. © 2008 Wiley-Liss, Inc.