Journal of Cellular Biochemistry

Trafficking and differentiation of mesenchymal stem cells

Authors

  • Zhao-Jun Liu,

    1. The DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami
    2. Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida
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  • Ying Zhuge,

    1. The DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami
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  • Omaida C. Velazquez

    Corresponding author
    1. The DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami
    2. Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida
    • Associate Professor of Surgery (Chief, Division of Vascular and Endovascular Surgery), (Director, Vascular Laboratory), The DeWitt Daughtry Family Department of Surgery, Leonard M. Miller school of Medicine, The University of Miami, Jackson Memorial Medical Center, 1611 NW 12th Avenue, East Tower 3016, Miami, FL 33136.
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Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous population of stem/progenitor cells with pluripotent capacity to differentiate into mesodermal and non-mesodermal cell lineages, including osteocytes, adipocytes, chondrocytes, myocytes, cardiomyocytes, fibroblasts, myofibroblasts, epithelial cells, and neurons. MSCs reside primarily in the bone marrow, but also exist in other sites such as adipose tissue, peripheral blood, cord blood, liver, and fetal tissues. When stimulated by specific signals, these cells can be released from their niche in the bone marrow into circulation and recruited to the target tissues where they undergo in situ differentiation and contribute to tissue regeneration and homeostasis. Several characteristics of MSCs, such as the potential to differentiate into multiple lineages and the ability to be expanded ex vivo while retaining their original lineage differentiation commitment, make these cells very interesting targets for potential therapeutic use in regenerative medicine and tissue engineering. The feasibility for transplantation of primary or engineered MSCs as cell-based therapy has been demonstrated. In this review, we summarize the current knowledge on the signals that control trafficking and differentiation of MSCs. J. Cell. Biochem. 106: 984–991, 2009. © 2009 Wiley-Liss, Inc.

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