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Neural crest-derived stem cells display a wide variety of characteristics

  1. Narihito Nagoshi1,2,
  2. Shinsuke Shibata1,
  3. Masaya Nakamura2,
  4. Yumi Matsuzaki1,
  5. Yoshiaki Toyama2,
  6. Hideyuki Okano1,*

Article first published online: 28 MAY 2009

DOI: 10.1002/jcb.22213

Issue

Journal of Cellular Biochemistry

Journal of Cellular Biochemistry

Volume 107, Issue 6, pages 1046–1052, 15 August 2009

Additional Information

How to Cite

Nagoshi, N., Shibata, S., Nakamura, M., Matsuzaki, Y., Toyama, Y. and Okano, H. (2009), Neural crest-derived stem cells display a wide variety of characteristics. J. Cell. Biochem., 107: 1046–1052. doi: 10.1002/jcb.22213

Author Information

  1. 1

    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

  2. 2

    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

*35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Publication History

  1. Issue published online: 23 JUL 2009
  2. Article first published online: 28 MAY 2009
  3. Manuscript Accepted: 21 APR 2009
  4. Manuscript Received: 4 SEP 2008

Funded by

  • Ministry of Education, Culture, Sports, Science and Technology
  • General Insurance Association of Japan

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Keywords:

  • neural crest-derived stem cells;
  • bone marrow;
  • dorsal root ganglia;
  • skin;
  • embryo;
  • adult

Abstract

A recent burst of findings has shown that neural crest-derived stem cells (NCSCs) can be found in diverse mammalian tissues. In addition to their identification in tissues that are known to be derived from the neural crest, recent studies have revealed NCSCs in tissues that are not specifically derived from the neural crest, such as bone marrow. NCSCs can express a wide range of characteristics, and which properties are expressed mainly depends on their tissue sources and the ontogenic stage of the animal. The identification of NCSCs in various tissues opens an entirely new avenue of approach to developing autologous cell replacement therapies for use in regenerative medicine. In this review, we discuss the origin, migration, and lineage potential of NCSCs from various mammalian tissue sources. J. Cell. Biochem. 107: 1046–1052, 2009. © 2009 Wiley-Liss, Inc.

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