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Runx transcription factors: Lineage-specific regulators of neuronal precursor cell proliferation and post-mitotic neuron subtype development
Article first published online: 8 JUN 2009
DOI: 10.1002/jcb.22221
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Zagami, C. J., Zusso, M. and Stifani, S. (2009), Runx transcription factors: Lineage-specific regulators of neuronal precursor cell proliferation and post-mitotic neuron subtype development. J. Cell. Biochem., 107: 1063–1072. doi: 10.1002/jcb.22221
Publication History
- Issue published online: 23 JUL 2009
- Article first published online: 8 JUN 2009
- Manuscript Accepted: 28 APR 2009
- Manuscript Received: 24 APR 2009
Funded by
- Canadian Institutes of Health Research. Grant Numbers: MOP-84577, MOP-42479
- Abstract
- Article
- References
- Cited By
Keywords:
- acute myeloid leukemia;
- dorsal root ganglion;
- motor neurons;
- nervous system;
- pain;
- proliferation;
- runx;
- sensory neurons;
- spinal cord
Abstract
runt-related (RUNX) genes encode evolutionarily conserved transcription factors that play essential roles during development and adult tissue homeostasis. RUNX proteins regulate the transition from proliferation to differentiation in a variety of cell lineages. Moreover, they control the diversification of distinct cellular phenotypes in numerous tissues. Alterations of RUNX functions are associated with several cancers and other human pathologies, underscoring the vital roles of these transcription factors in adult organs. Insights into the functions and regulations of mammalian RUNX proteins have been provided mostly by studies of RUNX involvement in mechanisms of hematopoietic and skeletal development and disease. A growing number of recent investigations are revealing new functions for RUNX family members during the development of the mammalian nervous system. This review will discuss recent progress in the study of RUNX protein involvement in mammalian neural development, with emphasis on the differentiation of olfactory, sensory, and motor neuron lineages. J. Cell. Biochem. 107: 1063–1072, 2009. © 2009 Wiley-Liss, Inc.