Tau as a potential novel therapeutic target in ischemic stroke
Article first published online: 17 NOV 2009
Copyright © 2009 Wiley-Liss, Inc.
Journal of Cellular Biochemistry
Volume 109, Issue 1, pages 26–29, 1 January 2010
How to Cite
Zheng, G.-Q., Wang, X.-M., Wang, Y. and Wang, X.-T. (2010), Tau as a potential novel therapeutic target in ischemic stroke. J. Cell. Biochem., 109: 26–29. doi: 10.1002/jcb.22408
- Issue published online: 21 DEC 2009
- Article first published online: 17 NOV 2009
- Manuscript Accepted: 8 OCT 2009
- Manuscript Received: 26 SEP 2009
- The Key Project of Wenzhou Municipal Science and Technology Bureau of Zhejiang Province, China. Grant Number: Y20070038
- tau proteins;
- ischemic stroke;
- therapeutic target
Stroke is associated with high mortality and major disability burdens worldwide, but there are few effective and widely available therapies. Tau plays an important role in promoting microtubule assembly and stabilizing microtubule networks with phosphorylation regulating these functions. Based on the “ischemia-reperfusion theory” of Alzheimer's disease, some previous studies have focused on the relationship of tau and Alzheimer lesions in experimental brain ischemia. Thus, we hypothesize that the alterations in phosphorylation of tau are critical to microtubule dynamics and metabolism, and contribute to the pathophysiologic mechanisms during brain ischemia and/or reperfusion processes. We infer that regulation of phosphorylation of tau may be considered as a potential new therapeutic target in ischemic stroke. J. Cell. Biochem. 109: 26–29, 2010. © 2009 Wiley-Liss, Inc.