Get access

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

Authors

  • Xiang-Shu Xian,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • Hyeyeon Park,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • Yu Kyung Cho,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • In Seok Lee,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • Sang Woo Kim,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • Myung-Gyu Choi,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • In-Sik Chung,

    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Search for more papers by this author
  • Ki-Hwan Han,

    1. Department of Anatomy, College of Medicine, Ewha Woman's University, Seoul, Korea
    Search for more papers by this author
  • Jae Myung Park

    Corresponding author
    1. Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    • Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, # 505, Banpo-Dong, Seocho-Gu, Seoul 137-701, Korea.
    Search for more papers by this author

Abstract

Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy. J. Cell. Biochem. 110: 321–332, 2010. © 2010 Wiley-Liss, Inc.

Get access to the full text of this article

Ancillary