Transcriptional repression in ES cells
Article first published online: 24 MAR 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Cellular Biochemistry
Volume 110, Issue 2, pages 288–293, 15 May 2010
How to Cite
Cheong, C. Y. and Lufkin, T. (2010), Transcriptional repression in ES cells. J. Cell. Biochem., 110: 288–293. doi: 10.1002/jcb.22576
- Issue published online: 21 APR 2010
- Article first published online: 24 MAR 2010
- Manuscript Accepted: 11 FEB 2010
- Manuscript Received: 3 FEB 2010
- stem cells;
- transcriptional repression;
- histone modification
The dynamics of embryonic stem cell pluripotency is orchestrated by an interplay of transcriptional and epigenetic regulation in a systematic and modular manner. While the ES cell stage is marked by multiple loci with bivalent chromatin marks that prepare genes for imminent activation on differentiation, this open chromatin conformation is tempered by repressive machinery that prevent premature expression of key developmental genes. This review serves to highlight key ES transcription factors and their known links to the epigenetic machinery via known protein complexes. J. Cell. Biochem. 110: 288–293, 2010. © 2010 Wiley-Liss, Inc.