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Smurf control in bone cells

Authors

  • Lianping Xing,

    1. Department of Pathology, University of Rochester School of Medicine, Rochester, New York 14642
    2. Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642
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  • Ming Zhang,

    1. Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642
    2. Department of Orthopaedics and Rehabilitation, University of Rochester School of Medicine, Rochester, New York 14642
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  • Di Chen

    Corresponding author
    1. Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642
    2. Department of Orthopaedics and Rehabilitation, University of Rochester School of Medicine, Rochester, New York 14642
    • Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642.
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Abstract

The homologous to the E6-assosiated protein carboxyl terminus (HECT) domain E3 ubiquitin ligase Smurf1 is the first E3 ligase to be implicated in regulating bone cell function. The involvement of Smurf1 in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review highlights recent works exploring Smurf-regulated biological processes in bone cells and highlights recent discoveries surrounding the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Moreover, we discuss the relevance of targeting the HECT E3s through the development of small-molecule inhibitors as an anticancer therapeutic strategy. J. Cell. Biochem. 110: 554–563, 2010. © 2010 Wiley-Liss, Inc.

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