FGFs in endochondral skeletal development

Authors

  • Catherine R. Degnin,

    1. Shriners Hospital and Molecular & Medical Genetics and Cell & Developmental Biology, Oregon Health & Sciences University, Portland, Oregon
    Search for more papers by this author
  • Melanie B. Laederich,

    1. Shriners Hospital and Molecular & Medical Genetics and Cell & Developmental Biology, Oregon Health & Sciences University, Portland, Oregon
    Search for more papers by this author
  • William A. Horton

    Corresponding author
    1. Shriners Hospital and Molecular & Medical Genetics and Cell & Developmental Biology, Oregon Health & Sciences University, Portland, Oregon
    • Director, Research Center, Shriners Hospital for Children, 3101 Sam Jackson Park Road, Portland, OR 97239.
    Search for more papers by this author

Abstract

The mammalian skeleton developments and grows through two complementary pathways: membranous ossification, which gives rise to the calvarial bones and distal clavicle, and endochondral ossification, which is responsible for the bones of the limbs, girdles, vertebrae, face and base of the skull and the medial clavicle. Fibroblast growth factors (FGFs) and their cognate FGF receptors (FGFRs) play important roles in regulating both pathways. However, the details of how FGF signals are initiated, propagated and modulated within the developing skeleton are only slowly emerging. This prospect will focus on the current understanding of these events during endochondral skeletal development with special attention given to concepts that have emerged in the past few years. J. Cell. Biochem. 110: 1046–1057, 2010. Published 2010 Wiley-Liss, Inc.

Ancillary