PRL-3 phosphatase and cancer metastasis
Article first published online: 29 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Cellular Biochemistry
Volume 111, Issue 5, pages 1087–1098, 1 December 2010
How to Cite
Al-Aidaroos, A. Q. O. and Zeng, Q. (2010), PRL-3 phosphatase and cancer metastasis. J. Cell. Biochem., 111: 1087–1098. doi: 10.1002/jcb.22913
- Issue published online: 29 NOV 2010
- Article first published online: 29 NOV 2010
- Accepted manuscript online: 4 NOV 2010 12:00AM EST
- Manuscript Accepted: 4 OCT 2010
- Manuscript Received: 1 OCT 2010
- PRL-3 phosphatase;
- cancer metastasis;
- cancer cell signaling
The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed. J. Cell. Biochem. 111: 1087–1098, 2010. © 2010 Wiley-Liss, Inc.