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Amelioration of systemic lupus erythematosus by withangulatin A in MRL/lpr mice

Authors

  • Lijuan Sun,

    1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
    2. Hubei Province Key Laboratory of Biotechnology of TCM, Hubei University, 368 Youyi Road, Wuhan 430062, China
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  • Lin Zhou,

    Corresponding author
    1. Department of Laboratory Medicine, Changzhen Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
    • Department of Laboratory Medicine, Changzhen Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
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  • Mingcang Chen,

    1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
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  • Renqian Zhong,

    1. Department of Laboratory Medicine, Changzhen Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
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  • Jianwen Liu

    Corresponding author
    1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
    • Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China, University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
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  • Lijuan Sun and Lin Zhou contributed equally to this work.

Abstract

We have previously reported the anti-inflammatory potential and the possible underlying mechanisms of Withangulatin A (WA), which is an active component isolated from Physalis angulata L. Here, we demonstrated that WA might improve the life quality, as well as reduced the accumulation of proteinuria symptoms and levels of anti-double-stranded DNA antibodies in MRL/lpr mice. Moreover, WA could improve renal histopathologic characteristics of MRL/lpr mice. Intriguingly, expression of B cell-activating factor (BAFF), BAFF-R and related gene in the spleen were significantly reduced in 10 mg/kg WA-treated mice compared with that in 5 mg/kg WA-treated mice and untreated mice. These findings indicate that WA might have a pleiotropic therapeutic effect through their immunosuppression via inhibiting BAFF signaling, which suggest a potential application of this active constituent in the treatment of SLE. J. Cell. Biochem. 112: 2376–2382, 2011. © 2011 Wiley-Liss, Inc.

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