Regulation of tenascin expression in bone
Article first published online: 15 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Cellular Biochemistry
Volume 112, Issue 11, pages 3354–3363, November 2011
How to Cite
Morgan, J. M., Wong, A., Yellowley, C. E. and Genetos, D. C. (2011), Regulation of tenascin expression in bone. J. Cell. Biochem., 112: 3354–3363. doi: 10.1002/jcb.23265
- Issue published online: 15 OCT 2011
- Article first published online: 15 OCT 2011
- Accepted manuscript online: 12 JUL 2011 01:22PM EST
- Manuscript Accepted: 1 JUL 2011
- Manuscript Received: 22 MAR 2011
- NIH NIA. Grant Number: AG22305
- NIAMS. Grant Number: R057547
- bone morphogenetic protein;
Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascin W (TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts. J. Cell. Biochem. 112: 3354–3363, 2011. © 2011 Wiley Periodicals, Inc.