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Regulation of tenascin expression in bone

Authors

  • Jessica M. Morgan,

    1. Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616
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  • Alice Wong,

    1. Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616
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  • Clare E. Yellowley,

    1. Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616
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  • Damian C. Genetos

    Corresponding author
    1. Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616
    • Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, 4206 VM3A, 1285 Veterinary Medicine Drive, Davis, CA 95616.
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Abstract

Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascin W (TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts. J. Cell. Biochem. 112: 3354–3363, 2011. © 2011 Wiley Periodicals, Inc.

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