1097-4644/asset/olbannerleft.jpg?v=1&s=586aefb5b324d0a899c8338e293753a524cbe672)
Article
Interaction of epidermal growth factor with initiators and complete carcinogens in the C3H10T1/2 cell culture System
Article first published online: 19 FEB 2004
DOI: 10.1002/jcb.240280102
Copyright © 1985 Alan R. Liss, Inc.
1097-4644/asset/cover.gif?v=1&s=c55ee036b3038496cb712d572571012ddd7c366c "Journal of Cellular Biochemistry")
Additional Information
How to Cite
Herschman, H. R. and Brankow, D. (1985), Interaction of epidermal growth factor with initiators and complete carcinogens in the C3H10T1/2 cell culture System. J. Cell. Biochem., 28: 1–6. doi: 10.1002/jcb.240280102
Publication History
- Issue published online: 19 FEB 2004
- Article first published online: 19 FEB 2004
- Manuscript Revised: 13 DEC 1984
- Manuscript Accepted: 13 DEC 1984
- Manuscript Received: 4 SEP 1984
- Abstract
- References
- Cited By
Keywords:
- epidermal growth factor;
- 12-O-tetradecanoylphorbol-13-acetate;
- EGF;
- TPA;
- promotion;
- initiation;
- transformation
Abstract
Unlike 12-O-tetradecanoylphorbol-l3-acctate, epidermal growth factor (EGF) could not promote the appearance of type III foci from initiated C3H10T1/2 cells. At appropriate concentrations, EGF induced the formation of type II colonies in the absence of any initiator. At higher concentrations, EGF suppressed the induction of both type II and type III colonies elicited by methylcholanthrene.