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Article
Structure and chromosomal localization of the human lymphotoxin gene
Article first published online: 19 FEB 2004
DOI: 10.1002/jcb.240290302
Copyright © 1985 Alan R. Liss, Inc.
1097-4644/asset/cover.gif?v=1&s=c55ee036b3038496cb712d572571012ddd7c366c "Journal of Cellular Biochemistry")
Additional Information
How to Cite
Nedwin, G. E., Jarrett-Nedwin, J., Smith, D. H., Naylor, S. L., Sakaguchi, A. Y., Goeddel, D. V. and Gray, P. W. (1985), Structure and chromosomal localization of the human lymphotoxin gene. Journal of Cellular Biochemistry, 29: 171–181. doi: 10.1002/jcb.240290302
Publication History
- Issue published online: 19 FEB 2004
- Article first published online: 19 FEB 2004
- Manuscript Revised: 9 JUL 1985
- Manuscript Accepted: 9 JUL 1985
- Manuscript Received: 2 FEB 1985
- Abstract
- References
- Cited By
Keywords:
- lymphotoxin;
- cytotoxic factor;
- gene structure;
- chromosome 6
Abstract
We have isolated, sequenced, and determined the chromosomal localization of the gene encoding human lymphotoxin (LT). The single copy gene was isolated from a human genomic library using a 32P-labeled 116 bp synthetic DNA fragment whose sequence was based on the NH2-terminal amino acid sequence of LT. The gene spans 3 kb of DNA and is interrupted by three intervening sequences. The LT gene is located on human chromosome 6, as determined by Southern blot analysis of human-murine hybrid DNA. Putative transcriptional control regions and areas of homology with the promoters of interferon and other genes are identified.