Vascular permeability factor: A unique regulator of blood vessel function
Article first published online: 19 FEB 2004
Copyright © 1991 Wiley-Liss, Inc.
Journal of Cellular Biochemistry
Volume 47, Issue 3, pages 219–223, November 1991
How to Cite
Connolly, D. T. (1991), Vascular permeability factor: A unique regulator of blood vessel function. J. Cell. Biochem., 47: 219–223. doi: 10.1002/jcb.240470306
- Issue published online: 19 FEB 2004
- Article first published online: 19 FEB 2004
- Manuscript Accepted: 22 JUL 1991
- Manuscript Received: 11 JUL 1991
- vascular endothelial growth factor;
Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent polypeptide regulator of blood vessel function. VPF promotes an array of responses in endothelium, including hyperpermeability, endothelial cell growth, angiogenesis, and enhanced glucose transport. VPF regulates the expression of tissue factor and the glucose transporter. All of the endothelial cell responses to VPF are evidently mediated by high affinity cell surface receptors. Thus, endothelial cells have a unique and specific spectrum of responses to VPF. Since each of the responses of endothelial cells to VPF are also elicited by agonists, such as bFGF, TNF, histamine and others, it remains a major challenge to determine how post-receptor signalling pathways maintain both specificity and redundancy in cellular responses to various agonists.