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Epigenetic modulation by TFII-I during embryonic stem cell differentiation

Authors

  • Dashzeveg Bayarsaihan,

    Corresponding author
    1. Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dentistry, University of Connecticut Health Center, 262 Farmington Avenue, Farmington, Connecticut 06030
    • Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dentistry, University of Connecticut Health Center, 262 Farmington Avenue, Farmington, CT 06030.
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  • Aleksandr V. Makeyev,

    1. Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dentistry, University of Connecticut Health Center, 262 Farmington Avenue, Farmington, Connecticut 06030
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  • Badam Enkhmandakh

    1. Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dentistry, University of Connecticut Health Center, 262 Farmington Avenue, Farmington, Connecticut 06030
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Abstract

TFII-I transcription factors play an essential role during early vertebrate embryogenesis. Genome-wide mapping studies by ChIP-seq and ChIP-chip revealed that TFII-I primes multiple genomic loci in mouse embryonic stem cells and embryonic tissues. Moreover, many TFII-I-bound regions co-localize with H3K4me3/K27me3 bivalent chromatin within the promoters of lineage-specific genes. This minireview provides a summary of current knowledge regarding the function of TFII-I in epigenetic control of stem cell differentiation. J. Cell. Biochem. 113: 3056–3060, 2012. © 2012 Wiley Periodicals, Inc.

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