Get access

Prokaryotic Nε-lysine acetylomes and implications for new antibiotics

Authors

  • Longxiang Xie,

    1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China
    Search for more papers by this author
  • Wu Li,

    1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China
    Search for more papers by this author
  • Jianping Xie

    Corresponding author
    1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China
    • Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
    Search for more papers by this author

Abstract

Protein Nε-acetylation, a post-translational modification widespread in eukaryotes and prokaryotes, has been intensively explored due to its crucial roles in multitudinous physiologic events including transcriptional regulation, metabolic regulation, etc. The particular hotspot is the relationship between acetylation and metabolic regulation. Protein acetylation major types and functions thereof, prokaryotic acetyltransferase, deacetylases, and acetylation sites of enzymes related to glycometabolism, together with the cross-talk between acetylation and other modification, such as the phosphorylation were summarized, with emphases on those from Mycobacteria. J. Cell. Biochem. 113: 3601–3609, 2012. © 2012 Wiley Periodicals, Inc.

Get access to the full text of this article

Ancillary