Zitao Zhang and Jin Fan contributed equally to this work.
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The release of glutamate from cortical neurons regulated by BDNF via the TrkB/Src/PLC-γ1 pathway†
Article first published online: 14 NOV 2012
DOI: 10.1002/jcb.24311
Copyright © 2012 Wiley Periodicals, Inc.
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How to Cite
Zhang, Z., Fan, J., Ren, Y., Zhou, W. and Yin, G. (2013), The release of glutamate from cortical neurons regulated by BDNF via the TrkB/Src/PLC-γ1 pathway. J. Cell. Biochem., 114: 144–151. doi: 10.1002/jcb.24311
- †
Publication History
- Issue published online: 14 NOV 2012
- Article first published online: 14 NOV 2012
- Accepted manuscript online: 6 AUG 2012 09:23AM EST
- Manuscript Accepted: 26 JUL 2012
- Manuscript Received: 25 MAY 2012
Funded by
- National Natural Science Foundation of China. Grant Number: 81071481
REFERENCES
- , , , , , , , . 2003. The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation. Int J Oncol 23: 1727– 1731.
- , , , . 2006. Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals. Neurochem Int 49: 80– 86.
- , , , , , . 2006. Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathway. J Neurobiol 66: 1437– 1451.
- , , . 2004. The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 23: 7957– 7968.
- , . 1999. Phospholipase C-gamma as a signal-transducing element. Exp Cell Res 253: 15– 24.
- , , , . 2008. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J Biol Chem 283: 12949– 12959.
- , , , , , , , , , . 2003. GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor. J Biol Chem 278: 49936– 49944.
- , , , , . 2010. Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. J Neurosci 30: 6188– 6196.
- , . 2010. Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem 285: 8207– 8217.
- , , . 2005. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opin Ther Targets 9: 153– 168.
- , , , , , , . 2006. Serotonin stimulates GnRH secretion through the c-Src-PLC gamma1 pathway in GT1-7 hypothalamic cells. J Endocrinol 190: 581– 591.
- , . 1996. Physiology of the neurotrophins. Annu Rev Neurosci 19: 289– 317.
- , , , , , , , , , . 2010. Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway. Oncogene 29: 739– 751.
- , , , , , , , . 2006. Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neuronal activity. Mol Cell Neurosci 31: 70– 84.
- , . 1990. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 11: 379– 387.
- , , , , , , , , , , . 2009. Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer 101: 327– 334.
- , , , , . 2003. Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem 10: 108– 115.
- , , , , , , . 2001. Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca(2+) and Na(+) in cultured cerebellar neurons. J Neurosci Res 66: 96– 108.
- , , , , , , . 2002. Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons. J Biol Chem 277: 6520– 6529.
- , , , , , . 2009. Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Proc Natl Acad Sci USA 106: 647– 652.
- , , , , , . 2001. A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells. Proc Natl Acad Sci USA 98: 10930– 10935.
- , , , , , , . 2010. PLCgamma-activated signalling is essential for TrkB mediated sensory neuron structural plasticity. BMC Dev Biol 10: 103.
- , , , , . 2007. Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes. J Mol Cell Cardiol 43: 308– 318.
- , , , , , , , , , . 2011. Enhanced catecholamine release in mice expressing PKB/SGK-resistant GSK3. Pflugers Arch 462: 811– 819.
- , , , , . 2004. Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord. Eur J Neurosci 20: 1769– 1778.
- . 2000. Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr 130: 1016S– 1022S.
- , , , , , , , , . 2004. BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol 167: 1205– 1215.
- , . 1994. Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons. Brain Res 652: 65– 70.
- , , , , , , . 1998. Brain-derived neurotrophic factor induces rapid and transient release of glutamate through the non-exocytotic pathway from cortical neurons. J Biol Chem 273: 27620– 27624.
- , , , , , , , , , , , , , , , , , , , , . 2011. CD44-SLC1A2 gene fusions in gastric cancer. Sci Transl Med 3: 77ra30.
- . 2003. A role for Src kinase in the regulation of glutamate release from rat cerebrocortical nerve terminals. Neuroreport 14: 1519– 1522.
- , , , , , . 1993. Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons. J Neurochem 60: 2111– 2123.
- , . 2006. Regulation of nicotinic acetylcholine receptors by tyrosine kinases in the peripheral and central nervous system: same players, different roles. Cell Mol Life Sci 63: 2818– 2828.
- , , . 2004. Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases. Proc Natl Acad Sci USA 101: 8774– 8779.
- , , , , , , , , , . 2011. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain Behav Immun 25: 322– 334.

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