The authors declare no conflict of interest.
Emerging molecular networks in Burkitt's lymphoma†
Article first published online: 14 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Cellular Biochemistry
Volume 114, Issue 1, pages 35–38, January 2013
How to Cite
Mangani, D., Roberti, A., Rizzolio, F. and Giordano, A. (2013), Emerging molecular networks in Burkitt's lymphoma. J. Cell. Biochem., 114: 35–38. doi: 10.1002/jcb.24358
- Issue published online: 14 NOV 2012
- Article first published online: 14 NOV 2012
- Accepted manuscript online: 17 AUG 2012 08:33AM EST
- Manuscript Accepted: 8 AUG 2012
- Manuscript Received: 26 JUL 2012
- BURKITT'S LYMPHOMA;
Burkitt's lymphoma (BL), one of the most aggressive tumors affecting humans, characterized by the constitutive activation of the Myc oncogene together with the alteration of many other genetic and epigenetic factors. Among them, the INK4a/ARF locus has been well documented to play a central role in BL. Recently, we have discovered that simultaneous deregulation of both DNA methylation patterns and the ubiquitin-dependent proteolysis system is required to completely inactive the INK4/ARF locus, opening new possibilities for treating Burkitt's lymphoma. In this review, we integrate our discovery with the general view of BL and propose a new comprehensive approach to analyze and manage this aggressive disease. J. Cell. Biochem. 114: 35–38, 2012. © 2012 Wiley Periodicals, Inc.