Prospects

Neural stem cells—trends and advances†‡

  1. Denis English1,
  2. Neel K. Sharma2,
  3. Kaushal Sharma2,
  4. Akshay Anand2,*

Article first published online: 18 FEB 2013

DOI: 10.1002/jcb.24436

Issue

Journal of Cellular Biochemistry

Journal of Cellular Biochemistry

Volume 114, Issue 4, pages 764–772, April 2013

Additional Information

How to Cite

English, D., Sharma, N. K., Sharma, K. and Anand, A. (2013), Neural stem cells—trends and advances. J. Cell. Biochem., 114: 764–772. doi: 10.1002/jcb.24436

Author Information

  1. 1

    Foundation for Florida Development and Research, Palmetto, Florida

  2. 2

    Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

*Associate Professor, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

  1. †

    Conflicts of interest: None.

  2. ‡

    Denis English and Neel K. Sharma contributed equally to this work.

Publication History

  1. Issue published online: 18 FEB 2013
  2. Article first published online: 18 FEB 2013
  3. Accepted manuscript online: 5 DEC 2012 08:02AM EST
  4. Manuscript Accepted: 23 OCT 2012
  5. Manuscript Received: 7 SEP 2012

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Keywords:

  • NEURAL STEM CELLS;
  • MESENCHYMAL STEM CELLS;
  • NEUROGENESIS;
  • REGENERATION;
  • BIOTHERAPEUTICS

Abstract

For many years, accepted dogma held that brain is a static organ with no possibility of regeneration of cells in injured or diseased human brain. However, recent preclinical reports have shown regenerative potential of neural stem cells using various injury models. This has resulted in renewed hope for those suffering from spinal cord injury and neural damage. As the potential of stem cell therapy gained impact, these claims, in particular, led to widespread enthusiasm that acute and chronic injury of the nervous system would soon be a problem of the past. The devastation caused by injury or diseases of the brain and spinal cord led to wide premature acceptance that “neural stem cells (NSCs)” derived from embryonic, fetal or adult sources would soon be effective in reversing neural and spinal trauma. However, neural therapy with stem cells has not been realized to its fullest extent. Although, discrete population of regenerative stem cells seems to be present in specific areas of human brain, the function of these cells is unclear. However, similar cells in animals seem to play important role in postnatal growth as well as recovery of neural tissue from injury, anoxia, or disease. J. Cell. Biochem. 114: 764–772, 2013. © 2012 Wiley Periodicals, Inc.

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