The authors declare that they have no competing interests.
Target network analysis of adiponectin, a multifaceted adipokine†
Article first published online: 14 MAR 2013
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Cellular Biochemistry
Volume 114, Issue 5, pages 1145–1152, May 2013
How to Cite
Chen, X. (2013), Target network analysis of adiponectin, a multifaceted adipokine. J. Cell. Biochem., 114: 1145–1152. doi: 10.1002/jcb.24457
- Issue published online: 14 MAR 2013
- Article first published online: 14 MAR 2013
- Accepted manuscript online: 28 NOV 2012 08:26AM EST
- Manuscript Accepted: 6 NOV 2012
- Manuscript Received: 26 JUN 2012
- National Natural Science Foundation of China. Grant Number: 81160048
- Research Fund of the University of Macau. Grant Number: MYRG161(Y2-L2)-ICMS11-CXP
- NETWORK ANALYSIS;
- SUCCESSFUL DRUG TARGET;
- CLINICAL TRIED DRUG TARGET;
- RESEARCH DRUG TARGET
Application of network analysis to dissect the potential molecular mechanisms of biological processes and complicated diseases has been the new trend in biology and medicine in recent years. Among which, the protein–protein interactions (PPI) networks attract interests of most researchers. Adiponectin, a cytokine secreted from adipose tissue, participates in a number of metabolic processes, including glucose regulation and fatty acid metabolism and involves in a series of complicated diseases from head to toe. Hundreds of proteins including many identified and potential drug targets have been reported to be involved in adiponectin related signaling pathways, which comprised a complicated regulation network. Therapeutic target database (TTD) provides extensive information about the known and explored therapeutic protein targets and the signaling pathway information. In this study, adiponectin associated drug targets based PPI was constructed and its topological properties were analyzed, which might provide some insight into the dissection of adiponectin action mechanisms and promote adiponectin signaling based drug target identification and drug discovery. J. Cell. Biochem. 114: 1145–1152, 2013. © 2012 Wiley Periodicals, Inc.