Journal of Cellular Biochemistry

ATDC5: An excellent in vitro model cell line for skeletal development

Authors

  • Yongchang Yao,

    1. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
    2. National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
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  • Yingjun Wang

    Corresponding author
    1. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
    2. National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
    • School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
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Abstract

The ATDC5 cell line is derived from mouse teratocarcinoma cells and characterized as a chondrogenic cell line which goes through a sequential process analogy to chondrocyte differentiation. Thus, it is regarded as a promising in vitro model to study the factors that influence cell behaviors during chondrogenesis. It also provides insights in exploring signaling pathways related to skeletal development as well as interactions with innovative materials. To date, over 200 studies have utilized ATDC5 to obtain lots of significant findings. In this review, we summarized the literature of ATDC5 related studies and emphasized the application of ATDC5 in chondrogenesis. In addition, the general introduction of ATDC5 including its derivation and characterization is covered in this article. J. Cell. Biochem. 114: 1223–1229, 2013. © 2012 Wiley Periodicals, Inc.

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