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Journal of Cellular Biochemistry

Current techniques in reprogramming cell potency

Authors

  • Firdaus Romli,

    1. Faculty of Biotechnology and Biomolecular Sciences, Department of Cell and Molecular Biology, Universiti Putra Malaysia, Serdang, Malaysia
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  • Noorjahan Banu Alitheen,

    1. Faculty of Biotechnology and Biomolecular Sciences, Department of Cell and Molecular Biology, Universiti Putra Malaysia, Serdang, Malaysia
    2. Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia
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  • Muhajir Hamid,

    1. Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia
    2. Faculty of Biotechnology and Biomolecular Sciences, Department of Microbiology, Universiti Putra Malaysia, Serdang, Malaysia
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  • Ruzila Ismail,

    1. Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia
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  • Nik-Mohd-Afizan Nik Abd. Rahman

    Corresponding author
    1. Faculty of Biotechnology and Biomolecular Sciences, Department of Cell and Molecular Biology, Universiti Putra Malaysia, Serdang, Malaysia
    • Faculty of Biotechnology and Biomolecular Sciences, Department of Cell and Molecular Biology, Universiti Putra Malaysia, Serdang, Selangor 43400 UPM, Malaysia.
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  • The authors indicate no potential conflicts of interest.

Abstract

The first successful attempt to reprogram somatic cell into embryonic-like stem cell was achieved on 2006. Since then, it had sparked a race against time to bring this wonderful invention from bench to bedside but it is not easily achieved due to severe problems in term of epigenetic and genomic. With each problem arise, new technique and protocol will be constructed to try to overcome it. This review addresses the various techniques made available to create iPSC with problems hogging down the technique. J. Cell. Biochem. 114: 1230–1237, 2013. © 2012 Wiley Periodicals, Inc.

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