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Journal of Cellular Biochemistry

Haemostatic role of intermediate filaments in adhered platelets: Importance of the membranous system stability

Authors

  • Doris Cerecedo,

    Corresponding author
    • Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional (IPN), Mexico City, Mexico
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  • Ivette Martínez-Vieyra,

    1. Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional (IPN), Mexico City, Mexico
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  • Ricardo Mondragón,

    1. Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados (CINVESTAV) del IPN, México City, Mexico
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  • Mónica Mondragón,

    1. Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados (CINVESTAV) del IPN, México City, Mexico
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  • Sirenia González,

    1. Unidad de Microscopía Electrónica, Centro de IInvestigación y de Estudios Avanzados (CINVESTAV) del IPN, México City, México
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  • Iván J. Galván

    1. Unidad de Microscopía Confocal, Centro de Investigación y de Estudios Avanzados (CINVESTAV) del IPN, Mexico City, Mexico
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  • Conflicts of interest: Nothing to declare.

Correspondence to: Dr. Doris A. Cerecedo Mercado, Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía (ENMH), IPN, Guillermo Massieu Helguera no. 239, Col. La Escalera Ticomán, 07320 México, D.F., México.

E-mail: dcereced@prodigy.net.mx

Abstract

The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored. J. Cell. Biochem. 114: 2050–2060, 2013. © 2013 Wiley Periodicals, Inc.

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