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SWI/SNF in cardiac progenitor cell differentiation

Authors

  • Ienglam Lei,

    1. Department of Cardiac Surgery, Cardiovascular Research Center, University of Michigan Medical School, Ann Arbor, Michigan
    2. Li Ka Shing Faculty of Medicine, Departments of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
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  • Liu Liu,

    1. Department of Cardiac Surgery, Cardiovascular Research Center, University of Michigan Medical School, Ann Arbor, Michigan
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  • Mai Har Sham,

    1. Li Ka Shing Faculty of Medicine, Departments of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
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  • Zhong Wang

    Corresponding author
    • Department of Cardiac Surgery, Cardiovascular Research Center, University of Michigan Medical School, Ann Arbor, Michigan
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Correspondence to: Zhong Wang, Department of Cardiac Surgery, Cardiovascular Research Center, University of Michigan Medical School, North Campus Research Complex, Ann Arbor, MI 48109.

Email: zhongw@med.umich.edu

Abstract

Cardiogenesis requires proper specification, proliferation, and differentiation of cardiac progenitor cells (CPCs). The differentiation of CPCs to specific cardiac cell types is likely guided by a comprehensive network comprised of cardiac transcription factors and epigenetic complexes. In this review, we describe how the ATP-dependent chromatin remodeling SWI/SNF complexes work synergistically with transcription and epigenetic factors to direct specific cardiac gene expression during CPC differentiation. Furthermore, we discuss how SWI/SNF may prime chromatin for cardiac gene expression at a genome-wide level. A detailed understanding of SWI/SNF-mediated CPC differentiation will provide important insight into the etiology of cardica defects and help design novel therapies for heart disease. J. Cell. Biochem. 114: 2437–2445, 2013. © 2013 Wiley Periodicals, Inc.

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