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Journal of Cellular Biochemistry

The balance mediated by miRNAs and the heme oxygenase 1 feedback loop contributes to biological effects

Authors

  • Ning Ma,

    1. Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China
    2. Translational Medicine Center of Northern China, Harbin, China
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  • Ying Xiang,

    1. Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China
    2. Department of Cell Biology, Medical School, Yangtze University, China
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  • Yanfen Zhang,

    1. Department of Laboratory Diagnosis, Affiliated Hospital of Harbin Medical University, Harbin, China
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  • Xia Zhao,

    1. Laboratory Medicine, Heilongjiang Nursing College, Harbin, China
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  • Lingyun Zhou,

    1. Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China
    2. Translational Medicine Center of Northern China, Harbin, China
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  • Xu Gao

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China
    2. Translational Medicine Center of Northern China, Harbin, China
    3. Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, China
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  • Ning Ma and Ying Xiang contributed equally to this work.
  • The authors declare no conflict of interest.

ABSTRACT

Heme oxygenase-1 (HMOX1) is a ubiquitously expressed inducible enzyme that degrades heme to carbon monoxide, biliverdin, and free iron ions. Since 1950, many studies have revealed the role of HMOX1 in reducing the impact of oxidative stress in many types of diseases, such as Alzheimer's disease, heart disease, and the development of tumors. These effects arise as a result of the removal of heme, the biological activities of the products of HMOX1 and the activity of HMOX1 itself. However, HMOX1 has some contradictory effects. The discovery of microRNAs (miRNAs) and their relationship with HMOX1 has provided a new direction for research in this field. Here, we discuss the role of a potential regulatory feedback loop between HMOX1 and miRNAs in pathological processes based on recently published data. We hope to describe a new mechanism for HMOX1 function based on miRNAs to address the contradictory results reported in the literature. J. Cell. Biochem. 114: 2637–2642, 2013. © 2013 Wiley Periodicals, Inc.

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