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jcb24684-sm-0001-FigS1.eps901KFig. S1. GLS1 expression levels in ErbB2 positive SK-BR-3 and MDA-MB-453 cells. Protein levels of ErbB2 and GLS1 in SK-BR-3 and MDA-MB-453 cells were determined by Western blotting. ErbB2 negative MCF-7 was included as a reference.
jcb24684-sm-0002-FigS2.eps721KFig. S2. Proposed new role of ErbB2 in promoting breast cancer cell proliferation. In addition to activation PI3K and MAPK pathways, ErbB2 activation enhances glutamine utilization which facilitates the metabolic transformation and cancer cell proliferation. NF-κB (p65) is an important mediator of this process; however, the underlying mechanism remains to be elucidated.

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