Disclose potential conflicts of interest: The authors declare no conflicts of interest.
ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation
Article first published online: 19 JAN 2014
© 2013 Wiley Periodicals, Inc.
Journal of Cellular Biochemistry
Volume 115, Issue 3, pages 498–509, March 2014
How to Cite
Qie, S., Chu, C., Li, W., Wang, C. and Sang, N. (2014), ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation. J. Cell. Biochem., 115: 498–509. doi: 10.1002/jcb.24684
- Issue published online: 19 JAN 2014
- Article first published online: 19 JAN 2014
- Accepted manuscript online: 3 OCT 2013 01:31AM EST
- Manuscript Accepted: 24 SEP 2013
- Manuscript Received: 18 JUL 2013
- NCI, National Institutes of Health (NIH). Grant Number: R01-CA129494
- Drexel University
Additional supporting information may be found in the online version of this article at the publisher's web-site.
|jcb24684-sm-0001-FigS1.eps||901K||Fig. S1. GLS1 expression levels in ErbB2 positive SK-BR-3 and MDA-MB-453 cells. Protein levels of ErbB2 and GLS1 in SK-BR-3 and MDA-MB-453 cells were determined by Western blotting. ErbB2 negative MCF-7 was included as a reference.|
|jcb24684-sm-0002-FigS2.eps||721K||Fig. S2. Proposed new role of ErbB2 in promoting breast cancer cell proliferation. In addition to activation PI3K and MAPK pathways, ErbB2 activation enhances glutamine utilization which facilitates the metabolic transformation and cancer cell proliferation. NF-κB (p65) is an important mediator of this process; however, the underlying mechanism remains to be elucidated.|
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