Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic

Authors

  • Yu Cai,

    Corresponding author
    1. School of Pharmacy, Jinan University, Guangzhou, China
    • Correspondence to: Yu Cai, PhD, School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

      E-mail: caiyu58@163.com

      Correspondence to: Yan Chen, PhD, Ontario Cancer Institute, University Health Network, 610 University Ave, Toronto, ON M5G 2M9, Canada.

      E-mail: yyanchen@yahoo.com

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  • Tiange Cai,

    1. School of Life Science, Liaoning University, Shenyang, China
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  • Yan Chen

    Corresponding author
    1. Ontario Cancer Institute, University Health Network, Toronto, Canada
    • Correspondence to: Yu Cai, PhD, School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

      E-mail: caiyu58@163.com

      Correspondence to: Yan Chen, PhD, Ontario Cancer Institute, University Health Network, 610 University Ave, Toronto, ON M5G 2M9, Canada.

      E-mail: yyanchen@yahoo.com

    Search for more papers by this author

ABSTRACT

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Although pathologic characteristics of this disease are clear and well established, much remains to be understood about this tumor, particularly at the molecular signaling level. Secreted signaling molecules of the Wnt family have been widely investigated and found to play a central role in controlling embryonic bone development, bone mass, and postnatal bone regeneration. A variety of studies also suggest that Wnt signaling pathway is closely associated with bone malignancies, including breast or prostate cancer induced bone metastasis, multiple myeloma, as well as osteosarcoma. Here, we provide an overview of the role of Wnt signaling pathway in osteosarcoma development and progression, highlighting the aberrant activation of Wnt pathway in this bone malignancy. We also discuss the potential therapeutic applications for the treatment of osteosarcoma targeting Wnt pathway. J. Cell. Biochem. 115: 625–631, 2014. © 2013 Wiley Periodicals, Inc.

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