Differences in Nuclear DNA Organization Between Lymphocytes, Hodgkin and Reed–Sternberg Cells Revealed by Structured Illumination Microscopy
Article first published online: 17 JUN 2014
© 2014 The Authors. Journal of Cellular Biochemistry published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Journal of Cellular Biochemistry
Volume 115, Issue 8, pages 1441–1448, August 2014
How to Cite
Righolt, C. H., Guffei, A., Knecht, H., Young, I. T., Stallinga, S., van Vliet, L. J. and Mai, S. (2014), Differences in Nuclear DNA Organization Between Lymphocytes, Hodgkin and Reed–Sternberg Cells Revealed by Structured Illumination Microscopy. J. Cell. Biochem., 115: 1441–1448. doi: 10.1002/jcb.24800
- Issue published online: 17 JUN 2014
- Article first published online: 17 JUN 2014
- Accepted manuscript online: 4 MAR 2014 12:23AM EST
- Manuscript Accepted: 27 FEB 2014
- Manuscript Received: 26 FEB 2014
- Canada Foundation for Innovation
- Canadian Institutes of Health Research
- Canadian Cancer Society Innovation Grant # 702443
- Carl Zeiss Canada
Additional supporting information may be found in the online version of this article at the publisher's web-site.
supporting information Fig. S1. Slices from a trinucleated Reed-Sternberg cell (A) and a tetranucleated Reed-Sternberg cell (B).
supporting information Fig. S2. Several images illustrating the granulometry tests discussed in the supplementary materials and methods.
supporting information Fig. S3. Granulometry input images for a lymphocyte (A), an H cell (B), a binucleated RS cell (C), a trinucleated RS cell (D), a tetranucleated RS cell (E), and a multinucleated RS cell (F).
supporting information Fig. S4. Granulometries and histogram-based cell properties measured from widefield images.
supporting information Fig. S5. SIM image of the UBF channel for a lymphocyte (A), an H cell (B), a binucleated RS cell (C), a trinucleated RS cell (D), a tetranucleated RS cell (E), and a multinucleated RS cell (F).
supporting information Movie S1. All z-positions for the cell shown in Figure 1A.
supporting information Movie S2. All z-positions for the cell shown in Figure 1B.
supporting information Movie S3. All z-positions for the cell shown in Figure 1C.
supporting information Movie S4. All z-positions for the cell shown in Figure S1A.
supporting information Movie S5. All z-positions for the cell shown in Figure S1B.
supporting information Movie S6. All z-positions for the cell shown in Figure 1D.
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