Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High-Fat Diet-Induced Obese Mice (pages 2067–2077)
Yo-Han Han, Ji-Ye Kee, Jinbong Park, Hye-Lin Kim, Mi-Young Jeong, Dae-Seung Kim, Yong-Deok Jeon, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Hong-Seob So, Raekil Park, Jong-Hyun Lee, Soyoung Shin, Su-Jin Kim, Jae-Young Um and Seung-Heon Hong
Version of Record online: 26 MAY 2016 | DOI: 10.1002/jcb.25509
ARC induced the AMPK activation resulting in down-modulation of adipogenesis-related factors including PPARγ, C/EBPα, fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase. This study demonstrates that ARC can reduce key adipogenic factors by activating the AMPK in vitro and in vivo.