Journal of Cellular Biochemistry

Cover image for Vol. 118 Issue 7

July 2017

Volume 118, Issue 7

Pages i–i, 1623–1945

  1. Cover

    1. Top of page
    2. Cover
    3. Issue Information
    4. Prospects
    5. Benchmark
    6. Fasttrack
    7. Articles
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      Cover Image, Volume 118, Number 7, July 2017 (page i)

      Sunny Dholpuria, Manish Kumar, Sandeep Kumar, Parul Sarwalia, Sandeep Rajput, Rakesh Kumar, Sachinandan De and Tirtha K. Datta

      Version of Record online: 2 MAY 2017 | DOI: 10.1002/jcb.25702

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      Cover: The cover image, by Tirtha K. Datta et al., is based on the Article Differential Expression of Newly Identified Long Intergenic Non-Coding RNAs in Buffalo Oocytes Indicating Their Possible Role in Maturation and Embryonic Development, DOI: 10.1002/jcp.25828.

  2. Issue Information

    1. Top of page
    2. Cover
    3. Issue Information
    4. Prospects
    5. Benchmark
    6. Fasttrack
    7. Articles
    1. You have free access to this content
  3. Prospects

    1. Top of page
    2. Cover
    3. Issue Information
    4. Prospects
    5. Benchmark
    6. Fasttrack
    7. Articles
    1. Orientation of the Mitotic Spindle in the Development of Tubular Organs (pages 1630–1633)

      Tao Zhong and Jun Zhou

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/jcb.25865

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      We examine and interpret recent literature that shows how tubular organ development relies on proper spindle orientation. In addition, we discuss how defects in this cellular process are associated with the pathogenesis of tubular organ diseases.

    2. Therapeutic Potential of Curcumin in Treatment of Pancreatic Cancer: Current Status and Future Perspectives (pages 1634–1638)

      Mina Hosseini, Seyed Mahdi Hassanian, Elham Mohammadzadeh, Soodabeh ShahidSales, Mina Maftouh, Hasan Fayazbakhsh, Majid Khazaei and Amir Avan

      Version of Record online: 15 MAR 2017 | DOI: 10.1002/jcb.25897

      Pancreatic cancer is among the leading cause of deaths due to cancer with extremely poor prognosis. Gemcitabine is being used in the treatment of patient with pancreatic ductal adenocarcinoma (PDAC), although, the response rate is bellow 12%. Therefore, identification of novel agents that either improves gemcitabine activity, within novel combinatorial approaches, or with a better efficacy than gemcitabine is warranted. The antitumor activity of curcumin in several tumors, including prostate, breast, and colorectal cancers have investigated. This review summarizes the current knowledge about possible molecular mechanisms of curcumin in PDAC with particular emphasis on preclinical/clinical studies in pancreatic cancer treatment.

    3. The Opportunity of Precision Medicine for Breast Cancer With Context-Sensitive Tumor Suppressor Maspin (pages 1639–1647)

      Margarida M. Bernardo, Sijana H. Dzinic, Maria J. Matta, Ivory Dean, Lina Saker and Shijie Sheng

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/jcb.25969

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      The current review discusses the possibility for maspin to serve as a cell type-specific and context-sensitive marker to improve the precision of breast cancer diagnosis and prognosis. The new perspectives point to new window of opportunity for designing novel maspin-based chemotherapeutic agents with improved anti-cancer potency.

  4. Benchmark

    1. Top of page
    2. Cover
    3. Issue Information
    4. Prospects
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    7. Articles
    1. Protein Expression Differences of 2-Dimensional and Progressive 3-Dimensional Cell Cultures of Non-Small-Cell-Lung-Cancer Cell Line H460 (pages 1648–1652)

      Maddaly Ravi, Divya K. Mohan and Bellona Sahu

      Version of Record online: 11 JAN 2017 | DOI: 10.1002/jcb.25800

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      Cancer cells grown as 3D cultures exhibit different properties compared to their 2D counterparts of which changes in protein expression are one such. We show the protein profile changes of the human non-small-cell-lung-cancer cell line H460 as 2D monolayers and as progressive 3D cultures from days 2 to 10. Understanding such protein prolife changes through progressive 3D culture phases can be useful for cancer protein biomarker discovery.

  5. Fasttrack

    1. Top of page
    2. Cover
    3. Issue Information
    4. Prospects
    5. Benchmark
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    7. Articles
    1. MicroRNA-22 Promoted Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting HDAC6 (pages 1653–1658)

      Guang-Qi Yan, Xue Wang, Fan Yang, Min-Liang Yang, Gui-Rong Zhang, Guo-Kun Wang and Qing Zhou

      Version of Record online: 7 MAR 2017 | DOI: 10.1002/jcb.25931

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      Genetic modified stem cells transplantation is a promising therapy strategy for accelerating periodontal regeneration and reconstruction. Overexpression of miR-22 promoted osteogenic differentiation of human periodontal ligament stem cells by inhibiting HDAC6 expression. The results suggested that miR-22 might be developed as a target of genetic modified stem cells therapy for periodontal diseases.

  6. Articles

    1. Top of page
    2. Cover
    3. Issue Information
    4. Prospects
    5. Benchmark
    6. Fasttrack
    7. Articles
    1. Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes (pages 1659–1669)

      Cheng-Yen Tsai, Su-Ying Wen, Shi-Yann Cheng, Chung-Hsing Wang, Yao-Chih Yang, Vijaya Padma Viswanadha, Chih-Yang Huang and Wei-Wen Kuo

      Version of Record online: 24 MAR 2017 | DOI: 10.1002/jcb.25785

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      It was observed that the dependence of PKCα/PKCδ on ROS production to enhance JNK and p38 phosphorylation mediated HG-induced cardiac Nrf2 expression and activation, indicating that HG induced cardiac Nrf2 activation occurs through PKCα/PKCδ—ROS—JNK/p38 signaling.

    2. FGF Suppresses Poldip2 Expression in Osteoblasts (pages 1670–1677)

      Sakie Katsumura, Yayoi Izu, Takayuki Yamada, Kathy Griendling, Kiyoshi Harada, Masaki Noda and Yoichi Ezura

      Version of Record online: 15 MAR 2017 | DOI: 10.1002/jcb.25813

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      We found that Poldip2 mRNA is expressed in osteoblastic MC3T3-E1 cells. As FGF controls osteoblasts and angiogenesis, FGF regulation was investigated in these cells. FGF suppressed the expression of Poldip2 in MC3T3-E1 cells in a time dependent manner. Protein synthesis inhibitor but not transcription inhibitor reduced the FGF effects on Poldip2 gene expression in MC3T3-E1 cells.

    3. Evidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress (pages 1678–1688)

      Sathish Kumar Natarajan, Ezhumalai Muthukrishnan, Oleh Khalimonchuk, Justin L. Mott and Donald F. Becker

      Version of Record online: 13 DEC 2016 | DOI: 10.1002/jcb.25825

      We show that pipecolate, which is an intermediate of the lysine catabolic pathway, protects mammalian cells against pathophysiological concentrations of hydrogen peroxide. The mechanism of protection is shown to involve the enzyme pipecolate oxidase, Akt signaling, and FoxO3. These findings contribute important new insights into pipecolate metabolism and expand its role in mediating cell signaling processes.

    4. Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells (pages 1689–1698)

      Nawel Merghoub, Hassan El Btaouri, Laila Benbacer, Saïd Gmouh, Chantal Trentesaux, Bertrand Brassart, Mohammed Attaleb, Claudie Madoulet, Thomas Wenner, Saaid Amzazi, Hamid Morjani and Mohamed El Mzibri

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/jcb.25826

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      Inula Viscosa extracts have been demonstrated to induce telomere shortening and apoptosis in cervical cancer HeLa and SiHa cells by involving a mitochondria-mediated signaling pathway. In the present study, we provide evidence that these effects are induced by the sesquiterpene lactone tomentosin present in these extracts.

    5. Alteration of Neurotrophic Factors After Transplantation of Bone Marrow Derived Lin-ve Stem Cell in NMDA-Induced Mouse Model of Retinal Degeneration (pages 1699–1711)

      Neeru Jindal, Avijit Banik, Sudesh Prabhakar, Kim Vaiphie and Akshay Anand

      Version of Record online: 11 JAN 2017 | DOI: 10.1002/jcb.25827

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      Our study reveals that Lin-ve stem cells may exert neuroprotective effect in damaged retina mediated by participation of neurotrophic factors induced by stem cell transplantation at the site of injury.

    6. Differential Expression of Newly Identified Long Intergenic Non-Coding RNAs in Buffalo Oocytes Indicating Their Possible Role in Maturation and Embryonic Development (pages 1712–1721)

      Sunny Dholpuria, Manish Kumar, Sandeep Kumar, Parul Sarwalia, Sandeep Rajput, Rakesh Kumar, Sachinandan De and Tirtha K. Datta

      Version of Record online: 11 JAN 2017 | DOI: 10.1002/jcb.25828

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      Described new non coding RNAs which could be important for deciding the development ability of buffalo oocytes. These intergenic sequences were demonstrated to have no coding potential, yet observed to be a potential precursor of other classes of miRNAs having role in cell regulation important for the functioning of ovarian tissues.

    7. A Flap Endonuclease (TcFEN1) Is Involved in Trypanosoma cruzi Cell Proliferation, DNA Repair, and Parasite Survival (pages 1722–1732)

      Ivan Ponce, Carmen Aldunate, Lucia Valenzuela, Sofia Sepúlveda, Gilda Garrido, Ulrike Kemmerling, Gonzalo Cabrera and Norbel Galanti

      Version of Record online: 29 DEC 2016 | DOI: 10.1002/jcb.25830

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      FLAP endonucleases (FEN) are involved both in DNA replication and repair. In spite of these important functions this enzyme was not yet studied in Trypanosoma cruzi, the ethiological agent of Chagas disease. Here we show the presence and enzymatic activity of a TcFEN1, that is involved in parasite DNA repair, cell proliferation, and survival.

    8. TRIAD1 Is a Novel Transcriptional Target of p53 and Regulates Nutlin-3a-Induced Cell Death (pages 1733–1740)

      Junwoo Lee, Sungkwan An, Yeong Min Choi, Jin Hyuk Jung, Li Li, Hong Meng, Yinmao Dong, Kyu Joong Ahn, In-Sook An and Seunghee Bae

      Version of Record online: 10 JAN 2017 | DOI: 10.1002/jcb.25831

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      In this manuscript, we, for the first time, demonstrated that TRIAD1 has a positive feedback loop with tumor suppressive factor p53 and is involved in Nutlin-3a-induced p53 activation and its cytotoxic effects.

    9. MCPIP1 Exogenous Overexpression Inhibits Pathways Regulating MYCN Oncoprotein Stability in Neuroblastoma (pages 1741–1755)

      Elżbieta Boratyn, Iwona Nowak, Małgorzata Durbas, Irena Horwacik, Anna Sawicka and Hanna Rokita

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/jcb.25832

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      We show that exogenous expression of the MCPIP1 protein affects levels or phosphorylation of MYCN oncoprotein and its partners such as Aurora A (Thr288), CDC2 (Tyr15 and Thr161), GSK3β (Ser9), and other key cellular components of Akt/mTOR signaling, which regulate MYCN stability and activation. Moreover, exogenous expression of MCPIP1 does not cause apoptosis. Our data extend knowledge on roles of MCPIP1 in neuroblastoma cells and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt/mTOR pathway.

    10. Calmodulin Regulated Spectrin Associated Protein 1 mRNA is Directly Regulated by miR-126 in Primary Human Osteoblasts (pages 1756–1763)

      Sandra Strassburg, Nikita Nabar, Florian Lampert, Sebastian M. Goerke, Dietmar Pfeifer, Günter Finkenzeller, Gerhard B. Stark and Filip Simunovic

      Version of Record online: 5 JAN 2017 | DOI: 10.1002/jcb.25838

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      This article investigates the targets of miR-126 in osteoblasts. Using gain-of-function and loss-of-function experiments followed by Microarrays we identify potential candidates. The calmodulin regulated spectrin associated protein 1 is confirmed as a direct target of miR-126 in osteoblasts.

    11. Comparison of Cytotoxic Activity in Leukemic Lineages Reveals Important Features of β-Hairpin Antimicrobial Peptides (pages 1764–1773)

      Marcus V. Buri, Heron F. Vieira Torquato, Carlos Castilho Barros, Jaime S. Ide, Antonio Miranda and Edgar J. Paredes-Gamero

      Version of Record online: 11 JAN 2017 | DOI: 10.1002/jcb.25844

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      Two leukemic cell lines were selected: one sensitive (K562) and the other resistant (KG-1) to, antimicrobial peptides and the causes of resistance were investigated.

    12. IRS1/β-Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells (pages 1774–1781)

      Jaqueline Cristina Fernandes, Ana Paula Nunes Rodrigues Alves, João Agostinho Machado-Neto, Renata Scopim-Ribeiro, Bruna Alves Fenerich, Fernanda Borges da Silva, Belinda Pinto Simões, Eduardo Magalhães Rego and Fabiola Traina

      Version of Record online: 15 MAR 2017 | DOI: 10.1002/jcb.25845

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      IGF1R, IRS1, β-catenin, and MYC are highly expressed in acute lymphoblast leukemia. IGF1 modulates β-catenin nuclear translocation and MYC expression in ALL cells. IRS1/β-catenin axis is activated and may contribute to MYC expression in ALL cells.

    13. c-Myc-Dependent Cell Competition in Human Cancer Cells (pages 1782–1791)

      Manish S. Patel, Heta S. Shah and Neeta Shrivastava

      Version of Record online: 15 MAR 2017 | DOI: 10.1002/jcb.25846

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      This study illustrates that the relative c-Myc levels define “winner” and “loser” during cell competition in human cancer where cells with lower c-Myc (shMyc) become “loser” when co-cultured with higher c-Myc cells (Myc/Myccontrol/scrMyc). This may occur by winner cells mediated elimination of loser cells through JNK-dependent apoptosis and engulfment of loser cells.

    14. Follicle-Stimulating Hormone β-Subunit Potentiates Bone Morphogenetic Protein 9-Induced Osteogenic Differentiation in Mouse Embryonic Fibroblasts (pages 1792–1802)

      Xiao-Ya Su, Xiang Zou, Qian-Zhao Chen, Yu-Hua Zeng, Ying Shao, Bai-Cheng He and Hong Liu

      Version of Record online: 17 MAR 2017 | DOI: 10.1002/jcb.25849

      FSHβ can promote BMP9-induced osteogenic differentiation in MEFs. Mechanistically, FSHβ may promote BMP9-induced activation of BMP/Smad signaling through the FSH/FSH receptor (FSHR)/cAMP dependent pathway in MEFs partly.

    15. Study of IL4-590C/T and IL6-174G/C Gene Polymorphisms in Type 2 Diabetic Patients With Chronic Kidney Disease in North Indian Population (pages 1803–1809)

      Km Neelofar, Jamal Ahmad, Arif Ahmad and Khursheed Alam

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/jcb.25853

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      The associations between common potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes and kidney dysfunction in north Indian type 2 diabetic patients with chronic kidney disease.

    16. Activated α2-Macroglobulin Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1 (pages 1810–1818)

      Darío G. Ferrer, Virginia Actis Dato, Javier R. Jaldín Fincati, Valeria E. Lorenc, María C. Sánchez and Gustavo A. Chiabrando

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/jcb.25857

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      α2M* increases intracellular colocalization between LRP1 and β1-integrin.

    17. Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice (pages 1819–1826)

      Ernesto Canalis and Stefano Zanotti

      Version of Record online: 9 MAR 2017 | DOI: 10.1002/jcb.25859

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      Notch signaling induces Hes1 and Hey 1, 2, and L in skeletal cells. We examined the role of HeyL in bone remodeling by studying the phenotype of HeyL null mice using uCT and histomorphometry. HeyL null mice were were not substantially different from wild type controls at 1 and 3 months of age.

    18. MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis (pages 1827–1838)

      An Hue Vy Tran, Se Hee Han, Joon Kim, Francesca Grasso, In San Kim and Ye Sun Han

      Version of Record online: 15 MAR 2017 | DOI: 10.1002/jcb.25866

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      MYH, which interacts with TRADD, inhibits TNF-α necroptotic signaling. MYH inactivation is essential for necroptosis via the downregulation of caspase-8.

    19. Rosmarinic Acid Mediates Mitochondrial Biogenesis in Insulin Resistant Skeletal Muscle Through Activation of AMPK (pages 1839–1848)

      Govindaraj Jayanthy, Vellai Roshana Devi, Kaliappan Ilango and Sorimuthu Pillai Subramanian

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/jcb.25869

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      Rosmarinic acid improves insulin sensitivity through regulating mitochondrial biogenesis in insulin resistant skeletal muscle.

    20. Assessment of IL-18 Serum Level and Its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients (pages 1849–1854)

      Nasimudeen R. Jabir, Chelapram K. Firoz, Mohammad A. Kamal, Ghazi A. Damanhouri, Mohammed Nabil Alama, Qamre Alam, Absarul Haque, Hussein A. Almehdar and Shams Tabrez

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/jcb.25870

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      In this article, we observed non-significant changes in the IL-18 SNP hotspots. However, the serum IL-18 level was found to be significantly elevated in CAD patients. The highest rise of around 36% was recorded in unstable angina (UA) patients.

    21. α-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Kγ in THP-1 Monocytes (pages 1855–1867)

      Jean-Marc Zingg, Angelo Azzi and Mohsen Meydani

      Version of Record online: 24 MAR 2017 | DOI: 10.1002/jcb.25871

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      In this study we characterize the molecular mechanisms and cellular consequences that are associated with the internalization of the CD36 scavenger receptors induced by vitamin E analogs. In particular, we observe the reduction of bacterial phagocytosis and lipid accumulation and the induction of the PI3Kgamma/Akt signal transduction leading to the stimulation of VEGF expression.

    22. Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions (pages 1868–1878)

      Martha L. Pinzón-Daza, Yenith Cuellar-Saenz, Francisco Nualart, Alejandro Ondo-Mendez, Lilia Del Riesgo, Fabio Castillo-Rivera and Ruth Garzón

      Version of Record online: 28 MAR 2017 | DOI: 10.1002/jcb.25890

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      We could suggest that Pgp and BCRP expression can be regulated via cross-talk between doxorubicin and hypoxia, promoting drug resistance in HT-29 WT and doxorubicin-resistant colon cancer cells and that this process may be ROS dependent.

    23. Evaluating the Protective Effects and Mechanisms of Diallyl Disulfide on Interlukin-1β-Induced Oxidative Stress and Mitochondrial Apoptotic Signaling Pathways in Cultured Chondrocytes (pages 1879–1888)

      Azam Hosseinzadeh, Davood Jafari, Tunku Kamarul, Abolfazll Bagheri and Ali M. Sharifi

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/jcb.25907

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      DADS inhibited IL-1β-induced ROS generation, lipid peroxidation as well as increasing Nrf2 nuclear translocation in chondrocytes. DADS increased the gene expression of detoxifying phase II and antioxidant enzymes. DADS decreased mitochondrial apoptosis markers including Bax protein expression, caspase-3 activation, and also JNK and P38 MAPKs phosphorylation. The protective effects of DADS may be due to its antioxidant properties by increasing Nrf2 nuclear translocation promoting the transcription of detoxifying phase II or antioxidant enzymes genes leading to reduction of oxidative stress. This protection could also be attributed to anti-apoptotic effect of DADs.

    24. LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway (pages 1889–1899)

      Yiwei Liao, Liangfang Shen, Haiting Zhao, Qing Liu, Jun Fu, Yong Guo, Renjun Peng and Lei Cheng

      Version of Record online: 13 FEB 2017 | DOI: 10.1002/jcb.25910

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      In the present study, we have demonstrated that CASC2 plays an important role in the chemo-resistance of glioma by functioning as a ceRNA to regulate the expression of key genes. CASC2 may potentially act as an effective therapeutic candidate combined with traditional TMZ-based chemo-therapy for glioma.

    25. Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach (pages 1900–1910)

      Sneha P, Kumar Thirumal D, Himani Tanwar, Siva R, George Priya Doss C and Hatem Zayed

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/jcb.25920

    26. The Role of c-SKI in Regulation of TGFβ-Induced Human Cardiac Fibroblast Proliferation and ECM Protein Expression (pages 1911–1920)

      Juan Wang, Liping Guo, Difei Shen, Xiao Xu, Jiaping Wang, Suxia Han and Wen He

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/jcb.25935

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      We revealed that c-Ski could repress, while miR-155/miR-17 could inhibit TGFβ1-induced cardiac fibroblast proliferation and ECM protein increase. The present study provided a potential therapy to treat cardiac fibrosis by inhibiting miR-155/miR-17 so as to restore the effect of c-Ski on suppressing TGFβ1 signaling.

    27. Endothelial Cells Inhibit the Angiotensin II Induced Phenotypic Modulation of Rat Vascular Adventitial Fibroblasts (pages 1921–1927)

      Jia-Ying Xu, Neng-Bin Chang, Tao Li, Rui Jiang, Xiao-Lei Sun, Yan-Zheng He and Jun Jiang

      Version of Record online: 24 MAR 2017 | DOI: 10.1002/jcb.25941

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      Under the influence of angiotensin II, adventitial fibroblasts were prone to undergo phenotypic modulation, which was closely related to vascular remodeling. Our study showed that endothelial cells influenced adventitial fibroblasts phenotypic transformation and such effect would be mediated through nitric oxide/cGMP signaling pathway.

    28. Resveratrol Enhances Self-Renewal of Mouse Embryonic Stem Cells (pages 1928–1935)

      Na Li, Zhaoyu Du, Qiaoyan Shen, Qijing Lei, Ying Zhang, Mengfei Zhang and Jinlian Hua

      Version of Record online: 29 MAR 2017 | DOI: 10.1002/jcb.25942

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      We uncovered a previously unappreciated function of RSV in promoting the pluripotent state of ESCs, and this effect depended largely upon the timing of RSV treatment and the working concentration of RSV. In accordance with this finding, RSV also enhanced the proliferation of ESCs.

    29. Transcriptome and Functional Genomics Reveal the Participation of Adenine Phosphoribosyltransferase in Trypanosoma cruzi Resistance to Benznidazole (pages 1936–1945)

      Paola García-Huertas, Ana María Mejía-Jaramillo, Laura González and Omar Triana-Chávez

      Version of Record online: 31 MAR 2017 | DOI: 10.1002/jcb.25978

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      Transcriptomic analysis revealed the regulation of different genes between benznidazole resistant and sensitive parasites. Functional characterization of adenine phosphoribosyltransferase (APRT) gene revealed of role of this gene in the resistance to this drug, which was confirmed overexpressing it in sensitive and resistant parasites.

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