Cover Image, Volume 33, Issue 24
Article first published online: 2 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Computational Chemistry
Volume 33, Issue 24, pages i–ii, 15 September 2012
How to Cite
(2012), Cover Image, Volume 33, Issue 24. J. Comput. Chem., 33: i–ii. doi: 10.1002/jcc.22079
- Issue published online: 2 AUG 2012
- Article first published online: 2 AUG 2012
- Cited By
A theoretical study of the hydrolysis of a b-lactam antibiotic, cefotaxime (CEF), in gas phase with semi-empirical and density functional theory (DFT) methods, and in aqueous solution by means of hybrid quantum mechanics/molecular mechanics (QM/MM) potentials, is presented on page 1948 by Conchín Meliá, Silvia Ferrer, Vicent Moliner, Iñaki Tuñón, and Juan Bertrán. The inclusion of the full molecule of the CEF in the gas phase molecular model has been demonstrated to be crucial since its carboxylate group can activate the nucleophilic water molecule. In aqueous solution, the free energy profiles show a step-wise mechanism that is kinetically determined by the nucleophilic attack of a water molecule which, in turn, can be activated by a proton transfer from the carboxylate group of the substrate (the first step). The image represents the molecule of CEF and the water molecule that hydrolizes the b-lactam ring.