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The cover picture shows a new method for generating protein loop variants using a complete library of polypeptides from the PDB, which are addressable using their geometric properties. This way it is possible to insert geometrically fitting and protein-like loops at high speed. As presented on page 2483 by Michael D. Tyka, Kenneth Jung, and David Baker, this algorithm is part of a larger hierarchical workflow, incorporating fast structure evaluators and can be parallelized on supercomputers with up to 128,000 compute cores with near perfect efficiency. Using this enhanced sampling power previously invisible deficiencies in the Rosetta force field are uncovered and an extensive decoy training set for optimizing and testing force fields is created.