Cover Image, Volume 34, Issue 20



The cover image shows predictions obtained by a computational optimization method called “multiobjective evolutionary algorithm with many tables” (MEAMT), an approach by Christiane Brasil et al. on page 1719 that can predict relevant protein structures in a purely ab initio way, considering four energy terms. The ability to handle many simultaneous objectives enables MEAMT to efficiently use the solvation energy and hydrogen bond interaction terms, which is essential to predict beta-sheet structures by a purely ab initio strategy. The predictions (in pink) appear aligned with their corresponding native structures (in cyan), such as gelsolin (1SOL, alpha-helix), 12-residues beta hairpin HP7 molecule (2EVQ, beta-sheet), and granulin A (1G26, beta-sheet).