GalaxyDock2 by Woong-Hee Shin et al. on page 2647 is a protein-ligand docking program that performs conformational space annealing (CSA) global optimization to find the optimal binding pose of a ligand both in the rigid-receptor mode and the flexiblereceptor mode. Compared to the earlier version, GalaxyDock2 is improved by the efficient generation of high-quality initial conformations for CSA using a predocking method based on a betacomplex derived from the Voronoi diagram of receptor atoms. The cover shows that docking in the flexible mode can be effectively performed using the beta-complex and global optimization. GalaxyDock2 is freely available at http://galaxy.seoklab.org/softwares/galaxydock.html.