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The size and complexity of proteins whose dynamic properties can be measured experimentally is increasing at a steady pace, but the theory allowing the interpretation of these results is lagging. On page 518, Mateusz Maciejewski et al. analyze the Brownian motion of a three-domain protein, showing that the interdomain dynamics of such systems can be described within the framework of the extended model-free formalism. These results are in excellent agreement with previous studies, and will provide a guideline for experimental studies of inter-domain dynamics in large multidomain proteins.