Cover Image, Volume 35, Issue 12
Article first published online: 2 APR 2014
Copyright © 2014 Wiley Periodicals, Inc.
Journal of Computational Chemistry
Volume 35, Issue 12, pages i–ii, 5 May 2014
How to Cite
(2014), Cover Image, Volume 35, Issue 12. J. Comput. Chem., 35: i–ii. doi: 10.1002/jcc.23600
- Issue published online: 2 APR 2014
- Article first published online: 2 APR 2014
- Cited By
On page 932 (DOI: 10.1002/jcc.23579), Sam Z. Grinter and Xiaoqin Zou introduce a new method of handing the sparse data problem in knowledge-based scoring functions and present the approach in a scoring function called STScore. This Bayesian statistical approach, though presented in the context of protein-ligand docking, may be used with other knowledge-based scoring functions for protein-protein docking and protein structure prediction. The cover compares the native binding mode of PDB:2cgr, correctly identified by STScore, with the binding mode predicted by a rudimentary potential of mean force. The cover also shows three example curves for the probability density function used in the derivation of STScore.