Differential geometric analysis of alterations in MH α-helices (pages 1862–1879)
Birgit Hischenhuber, Hans Havlicek, Jelena Todoric, Sonja Höllrigl-Binder, Wolfgang Schreiner and Bernhard Knapp
Article first published online: 24 MAY 2013 | DOI: 10.1002/jcc.23328
The structural characterization of the major histocompatibility complex α-helices in reaction to different loaded peptides and liganded T cell receptors is an essential step in understanding how very early T cell activation takes place. For this purpose, we introduce a new differential geometric methodology to characterize these helices in a structured and comparable way.