Original Article

Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy

  1. Kyouichi Tashiro,
  2. Ichiro Koyanagi,
  3. Akemi Saitoh,
  4. Ayumi Shimizu,
  5. Toshihide Shike,
  6. Chizuru Ishiguro,
  7. Michiko Koizumi,
  8. Kazuhiko Funabiki,
  9. Satoshi Horikoshi,
  10. Isao Shirato,
  11. Yasuhiko Tomino*

Article first published online: 8 JAN 2002

DOI: 10.1002/jcla.2057

Issue

Journal of Clinical Laboratory Analysis

Journal of Clinical Laboratory Analysis

Volume 16, Issue 1, pages 1–4, 2002

Additional Information

How to Cite

Tashiro, K., Koyanagi, I., Saitoh, A., Shimizu, A., Shike, T., Ishiguro, C., Koizumi, M., Funabiki, K., Horikoshi, S., Shirato, I. and Tomino, Y. (2002), Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy. Journal of Clinical Laboratory Analysis, 16: 1–4. doi: 10.1002/jcla.2057

Author Information

  1. Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

*Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

Publication History

  1. Issue published online: 8 JAN 2002
  2. Article first published online: 8 JAN 2002
  3. Manuscript Accepted: 24 AUG 2001
  4. Manuscript Received: 9 APR 2001

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Keywords:

  • urinary MCP-1;
  • IL-8;
  • type 2 diabetic nephropathy

Abstract

We examined the correlation among the levels of urinary monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), hyperglycemia, and renal injuries in patients with type 2 diabetic nephropathy. The levels of urinary MCP-1, IL-8, protein excretion, blood urea nitrogen (BUN), serum creatinine (s-Cr), glycohemoglobin A1c (HbA1c), and fasting plasma glucose (FPG) were measured in 24 patients with type 2 diabetic nephropathy and 14 healthy adults as controls. Diabetic nephropathy was classified into three stages: stage 1 = normoalbuminuric, stage 2 = microalbuminuric, and stage 3 = macroalbuminuric. All of the patients showed normal ranges in renal function tests. Levels of urinary MCP-1 in all patients with diabetic nephropathy were significantly higher than those in healthy adults (P < 0.05). The levels of urinary MCP-1 in patients with diabetic nephropathy increased gradually according to the clinical stage of this disease. In contrast, the levels of urinary IL-8 in patients with diabetic nephropathy increased in stages 2 and 3. There was a significant correlation between the levels of urinary IL-8 and those of HbA1c. High glucose may stimulate MCP-1 and/or IL-8 production and their excretion into the urine independently of the phases or pathological lesions of this disease. It appears that IL-8 increased in the early stage of diabetic nephropathy, and MCP-1 increased in the advanced stage of this disease. It was concluded that measurement of urinary MCP-1 and IL-8 may be useful for evaluating the degree of renal injuries in patients with type 2 diabetic nephropathy. J. Clin. Lab. Anal. 16:1–4, 2002. © 2002 Wiley-Liss, Inc.

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