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Association of Genetic Variations in X-Ray Repair Cross-Complementing Group 1 and Tourette Syndrome

Authors

  • Wei-Yong Lin,

    1. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
    2. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
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    • These authors contributed equally to this work.

  • Cheng-Chun Lee,

    1. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    2. School of Medicine, China Medical University, Taichung, Taiwan
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    • These authors contributed equally to this work.

  • Hsin-Ping Liu,

    1. Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan
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  • I-Ching Chou,

    1. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
    2. Children's Medical Center, China Medical University Hospital, Taichung, Taiwan
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  • Jim Jinn-Chyuan Sheu,

    1. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    2. School of Chinese Medical Science, China Medical University, Taichung, Taiwan
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  • Lei Wan,

    1. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    2. School of Chinese Medical Science, China Medical University, Taichung, Taiwan
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  • Ying-Ju Lin,

    1. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    2. School of Chinese Medical Science, China Medical University, Taichung, Taiwan
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  • Yuhsin Tsai,

    1. School of Chinese Medical Science, China Medical University, Taichung, Taiwan
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  • Fuu-Jen Tsai

    Corresponding author
    1. Children's Medical Center, China Medical University Hospital, Taichung, Taiwan
    2. School of Chinese Medical Science, China Medical University, Taichung, Taiwan
    3. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
    • Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
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  • Grant sponsor: National Science Council in Taiwan; Grant numbers: NSC 97–2320-B-039–021-MY3; NSC 99–2320-B-039–024; Grant sponsor: China Medical University & Hospital; Grant numbers: CMU97-CMC-018; CMU97-CMC-003; CMU97–301; CMU97–265; CMU97–157; DMR-98–063; DMR-95–015; DMR-93–001; Grant sponsor: Taiwan Department of Health Clinical Trial and Research Center of Excellence; Grant number: DOH101-TD-B-111–004.

Correspondence to: Fuu-Jen Tsai, Department of Medical Research, China Medical University Hospital, Taiwan, No. 2 Yuh Der Road, Taichung 404, Taiwan. E-mail: d0704@www.cmuh.org.tw

Abstract

Background

X-ray repair cross-complementing group 1 (XRCC1) plays a central role in mammalian DNA repair process. The polymorphism rs25487 (Arg>Gln at codon 399) of this gene is common in Han Chinese population.

Objectives

The objective of this study was to analyze the association between this functional SNP of XRCC1 and Tourette syndrome (TS) in Han Taiwan Chinese population.

Methods

Genotyping was performed by using PCR–RFLP method on 73 TS patients and 158 normal controls.

Results

Our data indicated that genotype frequency of A/G polymorphism at codon 399 of the patients differed from the controls (P = 0.026, OR: 2.22, 95% CI: 1.22–4.03). The allele frequency analysis also showed significant differences with higher A allele frequency in patients (P = 0.015, OR: 1.70, 95% CI: 1.11–2.62).

Conclusion

Our study indicates that the functional SNP at codon 399 of XRCC1 is associated with TS development. J. Clin. Lab. Anal. 26:321-324, 2012. © 2012 Wiley Periodicals, Inc.

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