This article attempts to revitalize the scientist-practitioner model of psychotherapy by focusing on the research component of the model. Specifically, it takes a realistic look at the types of research that can be conducted by clinicians in an effort to motivate them to engage regularly in clinical research. Towards this end, five experienced scientist-practitioners explore the advantages, disadvantages, and potential of practitioner-initiated research. The problems and solutions for such research are discussed, and recommendations are offered. © 2002 Wiley Periodicals, Inc. J Clin Psychol 58: 1241–1264, 2002.