The approach that mental health professionals have taken in working with gay, lesbian, and bisexual (GLB) clients has changed dramatically over the past 25 years. Once viewed as being pathological in nature—either a sociopathic personality disorder or a sexual deviation—homosexuality is no long conceptualized as a “disorder” and instead is viewed within the broader context of human diversity. Even with such changes, many mental health professionals nonetheless retain subtle biases against working with gay, lesbian, and bisexual clients, and often lack the necessary information for working with them effectively. This issue of In Session provides a series of articles designed to help practicing therapists to become better aware of those clinical issues if they are to work with GLB individuals—which they are likely to do. © 2001 John Wiley & Sons, Inc. J Clin Psychol/In Session 57: 609–613, 2001.