Cognitive–behavioral therapy (CBT) can be adapted to a wide range of clinical difficulties and presenting problems that face lesbians, gay men, and bisexual persons. The following article presents general guidelines for and two case examples of the use of CBT. The first case is a gay male struggling with social phobia. This case is an example of how to adapt a structured, empirically supported cognitive–behavioral treatment focusing on social phobia to situations that are associated with his sexual orientation. The second is a woman struggling with multiple issues including coming out. This case provides an example of how to add specific cognitive–behavioral techniques to coming-out issues within the context of a more eclectic, longer-term therapy. © 2001 John Wiley & Sons, Inc. J Clin Psychol/In Session 57: 629–643, 2001.