In this study, we compared the Minnesota Multiphasic Personality Inventory—2 (MMPI-2) performance of male university students and incarcerated criminal offenders in Mexico. Our aim was to determine whether the MMPI-2 can effectively differentiate between these two distinct groups on scales that are reflective of antisocial behaviors. Our expectations were highly confirmed across the three sets of scales that we considered: the validity and clinical, content, and supplementary scales. Criminal offenders obtained higher or more pathological scores on such scales as Infrequency (F), Schizophrenia (Sc), MacAndrew Alcoholism Scale (MAC-R), Fears (FRS), and so on. Overall, these findings support further research with such target populations as prison inmates in Mexico and other countries in Latin America. © 2002 Wiley Periodicals, Inc. J Clin Psychol 58: 465–470, 2002.