Multiculturalism and evidence-based practice (EBP) in psychotherapy hailed from disparate sources and rarely interacted. These strange bedfellows have become fast friends in recent years as they recognize their crucial interdependence: multiculturalism without strong research risks becoming an empty political value and EBP without cultural sensitivity risks irrelevancy. In this article, the authors reviewed various incarnations and recent manifestations of their overdue intersection, including several conferences, federal initiatives, and organizational accomplishments. They introduced the subsequent 6 articles in this special issue of the Journal of Clinical Psychology: In Session, which described and illustrated cultural-sensitive evidence-based practices. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 66:1–9, 2010.